Background: Pressure ulcers in orthopedic patients are a major health concern with greater expectations of their development. It should be monitored in all admitted patients with a high risk for developing it. Orthopedic nursing staff must be aware with procedures required to avoid and minimize its incidence. Aim of this study: To evaluate the effect of pressure ulcer prevention program on nurses' performance and orthopedic patients' outcomes. Method: Quasi-experimental design was used to carry out the study. Sample of thirty-six nurses and eighty patients were recruited from orthopedic departments at South Valley University Hospital. Tools: Four tools included as follow a structured interview questionnaire; nurses' pressure ulcer preventive practices observational checklist, comprehensive skin assessment tool, and Braden Scale were utilized to assemble data. Results: The study showed that nurses' knowledge and practices were significantly improved towards pressure ulcer prevention after program implementation when compared to preprogram. Furthermore, there was a statistically significant difference in patient outcomes between the study and control groups (p< 0.05). Conclusion: The pressure ulcer prevention program has improved both nurses' performance and patients' outcomes. Recommendation: Providing continuing educational and training programs for nurses caring of orthopedic patients in order to strengthen their knowledge and practice related prevention of pressure ulcer.