Background: Safety is defined as the state of being free from accidental injury. In the context of healthcare, patient safety refers to the efforts aimed at minimizing patients' exposure to hazards, near-misses, and unnecessary harm associated with healthcare. Nurse interns constitute a significant portion of the healthcare workforce and play a vital role in improving patient safety. Aim: This study aims at assessing nurse interns' performance related to patient safety. Research design: A descriptive design was used to carry out this study. Study setting: The study was conducted at Ain-Shams University Hospitals. Study subjects: 139 nurse interns' whom are path from fourth year at faculty of nursing Ain-Shams University. Tools: Data were collected by using observational checklist for nurse interns' safety performance. Result: Demonstrates that  88.5% of nurse interns  performed task concerning prevention healthcare acquired infections unlike the other patient safety tasks. Conclusion: Nurse interns in the study settings need to upgrade performance related to patient safety. Recommendations: It is strongly recommended using training programs as a method of teaching to improve nurse interns' performance in various clinical areas of training during internship year.