Noninvasive positive pressure ventilation is becoming more common in treating acute respiratory
failure, it shortens hospital stays, time spent in the intensive care units, morbidity, and mortality.
This study aimed to assess the nurses' knowledge regarding non-invasive positive pressure in acute
respiratory failure. A descriptive cross-sectional research design was applied at the emergency
departments of Hail General Hospital and King Khaled Hospital in Saudi Arabia. A convenient
sample consisted of all available nurses who agreed to participate in the study (males & females)
were recruited (68 nurses). Nurses' knowledge was evaluated using a self-administered online
questionnaire developed by the researchers. Results revealed that reveals that, the studied nurses
had satisfactory knowledge scores as regards to definition, benefits, nursing roles, purposes, and
side effects of non-invasive positive pressure (NIPV). However, they had unsatisfactory knowledge
regarding indications and modes. The study results concluded that (69.1%) of the nurses had
overall total satisfactory knowledge scores regarding NIPV. The development of evidence-based
clinical guidelines and protocols is recommended.