Background: Second-degree burn represents an extremely stressful experience for both the burn client as well as their families, second-degree burn profoundly affects the client's physical, psychological, financial situation and family relations. Aim: Assess health needs and problems among clients with second-degree burn during follow-up. Research design: A descriptive design was used. Setting: The study was conducted at the Outpatient Burn & Plastic Clinic at Suez Canal University Hospital at Ismailia Governorate, Egypt. Sample: Purposive sample composed of 150 clients with second-degree burn who attended to the previously mentioned setting. Tool: Data were collected using one tool; A structured Interviewing questionnaire consists of 6 parts; (1) Socio-demographic characteristics of the participants, (2) Burn characteristics, (3) clients' knowledge, (4) clients' reported practices related to second-degree burn, (5) Health needs, and (6) Health problems among clients with second-degree burn. Results: The study revealed that 60.7% of clients with second-degree burn had unsatisfactory level of total knowledge regarding burn, and 65.3% of them had incorrect level of total reported practices towards care of burn. Furthermore, there were 71.3% of the studied clients their total physical, psychological, social and financial health needs were not achieved, while, 67.7% of them had physical, psychological, social and financial problems related to their second-degree burn. Conclusion: More than two-thirds of the studied clients their health needs were not achieved, and suffered from health problems related to second-degree burn. There was a highly statistically significant relation between clients' knowledge, reported practices regarding second-degree burn and their health needs. While, there was a statistically significant relation between clients' knowledge regarding second-degree burn and their health problems. Additionally, there was a highly statistically significant relation between clients' reported practices and their health problems. Recommendations: Establishing Health education programs for clients with second-degree burn to improve their level of knowledge and practices regarding burn. Further studies are needed to determine the health needs and problems of clients at different age stages with every degree of burn using large group size, and different settings.