Background: Caregivers of patient with hepatocellular carcinoma have great burden in caring their patients and having crucial role for management of their diseases. Aim: the current study aimed to assess caregivers' awareness toward health care of their patients with hepatocellular carcinoma. Research Design: A descriptive design was used. Sample: Purposive sample of 130 caregivers of patients with hepatocellular carcinoma Setting: The study was conducted at outpatient clinic in liver tumor clinic in Ain Shams University Specialized Hospital. Tools: Two tools were used for data collection. First tool: interviewing questionnaire was divided into three parts: Demographic data of patients and their caregivers, medical history of patient, caregivers' knowledge, and reported practices of caregivers. Second tool Likert scale to assess attitude of caregivers. Results: 54.6% of the caregivers had satisfactory knowledge, 91.5% of the caregivers had adequate reported practices, and 73.1% of the caregivers had positive attitude. Conclusion: there is a highly statistically significant relation between caregivers' total level of knowledge and their total practices; there is no statistically significant relation between caregivers' total level of knowledge and their total attitude. Also, there is a statistically significant relation between caregivers' total attitude and their total practices. Recommendations: Information related to health care services should be disseminated for the caregivers and Enhancement of nurses' role in health education hepatocellular carcinoma caregivers, encourage patients' coping strategies to overcome their condition.