This study aimed to evaluate the effect of self-instructional module on women's self-care practices regarding dysfunctional uterine bleeding during premenopause. Quasi-experimental study design regulated by a pre-test and a post-test was used. A purposive sample was used to recruit ninety five women suffering from dysfunctional uterine bleeding in the study. Five tools of data collection were used first tool was Structured Arabic Interviewing Questionnaire Sheet, second tool was Pictorial chart to calculate the abundance of lost blood; third tool was women self-care practices check list. Fourth tool was Likert scale; fifth tool was follow up card. The result of the study This study revealed that there was highly significant improvement regarding most of studied women's self-care practices regarding dysfunctional uterine bleeding before ,after and during follow up of implementing the self instructional module .Also this study showed that there was highly statistically significant differences between the studied women's total knowledge, total attitude and total self care practice score regarding dysfunctional uterine bleeding before and post implementing self –instructional module. Moreover there was significant correlation between total severity of dysfunctional uterine bleeding and total self-care practices of studied women regarding dysfunctional uterine bleeding before, after and during follow up of implementing the self instructional module. Conclusion and recommendations: The present study concluded that the result of this study support the research hypothesis that was the self-instructional module will enhance women's self-care practices regarding dysfunctional uterine bleeding during premenopause. Accordingly, the following recommendation is proposed: develop and implement educational program in the gynecology outpatient unit for premenopausal women to improve their knowledge and self care practices regarding Dysfunctional uterine bleeding.