Background: Universally, nurses are a major force in the fight against COVID-19 which may have been reflected in nurses' resilience affects the quality and safety of the care for patients afflicted with the virus. Aim: This study aimed to the effect of training program About COVID-19 on staff nurses' resilience. Design: A quasi-experimental one-group pretest-post-test design was conducted in this study. Setting: Banha University Hospital. Subjects: A simple random sample of 150 staff nurses. Tools: Data for this study were collected by using two tools, namely: knowledge, attitude, and practice (KAPs) concerning the COVID-19 questionnaire, and the resilience scale for nurses. Results: This study revealed that staff nurses' knowledge, attitude, and infection prevention practice regarding COVID-19 during the post- and follow-up intervention was improved. Also, the staff nurses' resilience level at the post- and follow-up intervention was increased. Conclusion: There was a positive strong statistically significant correlation between knowledge, attitude, infection prevention practice, and total level of resilience scores post and follow-up training program. Recommendations: Necessary resources should be available to allow nurses to work in a safe environment that may help in increasing resilience level during the fight against COVID-19, and the suggested future study to investigate the effect of COVID-19 on the performance quality of nurses and patient satisfaction.