Background: Nursing stress is considered a problem that affects the practice worldwide. Job stress is a harmful response physically and emotionally when the nurses' skills, resources, and needs could not fulfill the requirement of the job. Aim:  This study aimed to assess the effect of mindfulness based stress reduction program on psychiatric nurses' job stress and burnout Subject and Methods: This study was exploratory descriptive research design, Sampling: A convenient sample was selected while this study was performed on 30 psychiatric nurses working at Al-Abbassia Mental Health Hospital and Data were collected using 1) Socio-demographic sheet, 2) Psychiatric Nurses Job Stress Scale and 3) Maslach Burnout Inventory. Results: The main results showed that psychiatric nurses suffering from a different aspect of stress regarding psychiatric nurses' ability, the attitude of patient, attitude to nursing and communication with patients and their families. Also, the results indicated that mostly psychiatric nurses have high job burnout. Furthermore, there was a statistically significant relation between stress, burnout, and socio demographic data of nurses under study. Conclusions: the study concluded that psychiatric nurses working at Al-Abbassia mental health hospital had job stress and burnout. Recommendations:  This study recommended that, establish a psycho educational Program for psychiatric nurses to teach them how to cope positively with their stressors. Training programs and courses would help the psychiatric nurse to enhance their stress bearing capacity and improve their work performance.