Introduction: Esophageal Atresia is marked by heavy oral secretions, vomiting, and failure to pass a suction catheter or nasogastric tube at birth, and unexplained cyanosis after initial feeding. Oral intake reaches the lungs or large quantities of air enter the stomach if there is a fistula between the esophagus and trachea. Here may be crucial abdominal distension, choking, cyanosis, frothy white bubbles in the mouth, and coughing.  Aim of the Study: was to evaluate effect of mothers' telenursing program on specific postoperative outcomes for their infants with esophageal atresia. Research Design: In the present study, post and pre test quasi-experimental research design was applied. Setting: The suggested study was carried out at Cairo University Specialized Pediatric Hospital (CUSPH) in two separate locations. The first location was the SNICU (Surgical Neonatal Intensive Care Unit), and the second was the follow-up out-patient surgery clinic. Sample: Throughout the study, a purposeful sample of 60 women and their infants from past settings were selected. The study as well as control groups were split equally between the two categories. Tools of data collection: Mothers' Knowledge of EA, a Structured Interview Questionnaire, and a Follow-Up Phone Call for Selected Postoperative Outcomes Record Sheet for Infants are three Arabic-language data collection tools that were created by researchers. Results: The knowledge of mothers before and after the execution of the telenursing intervention programme showed highly statistically significant variations. Conclusion: The current study showed that, whenever telenursing was employed, it substantially enhanced mothers' knowledge in the study group compared with the control group. In addition, in comparison with women in the control group, infants with EA showed less postoperative difficulties for mothers who received the telenursing program. Recommendations: It is critical to use telenursing interventions in nursing care to make it simpler for mothers to reach in contact via nurses whenever they need to. For proof of how telenursing intervention may improve mothers' awareness of care following surgery over the course of a larger sample size, more study is needed.