Background: Staff satisfaction is a target for any organization, especially in a caring profession 
suffering from a shortage and requires staff retention increase as nursing. Work effectiveness and 
engagement as work issues and organizational climate represented in human relation and rational 
goal could be varied in their effect on nurses' satisfaction. Aim: Assess the effect of work issues and 
organizational climate on nurses' satisfaction. Subjects & Methods: The study was conducted on 
staff nurses at governmental hospitals in Ismailia city following predictive correlational design. 
Four tools were used for data collection: The Satisfaction Faces Scale; Global Empowerment Scale; 
Utrecht Work Engagement Scale; Organizational Climate Measure. Results: There are positive 
significant correlations among the studied variables. Work effectiveness and engagement were 
significant independent predictors of nurses' satisfaction (β= 0.651 and 0.546, p<0.01, respectively) 
whereas human relation and rational goal were significant independent predictors of nurses' 
satisfaction (β= 0.411 and 0.224, p<0.01, respectively). The combined effect of work effectiveness 
and engagement represented/explained 51.1% of the variance in nurses' satisfaction whereas, the 
combined effect of human relation and rational goal represented/explained 17.1% of the variance in 
nurses' satisfaction. Conclusion: Both work issues and organizational climate improve nurses' 
satisfaction. Work issues have a greater effect on nurses' satisfaction than organizational climate. 
Recommendations: To improve nurses' satisfaction, taking needed measures towards work 
engagement increase and structural empowerment for work effectiveness improvement, considering 
human relation and rational goal improvement are recommended. Also, hypothesized models
relating perceptions of work issues and organizational climate to nurses' satisfaction could be 
activated as strategies of evidence-based management for nurses' satisfaction.