Background: Breast-feeding had been linked to an increase in newborn jaundice during the first postnatal days. Unconjugated hyperbilirubinemia prolongation in breastfed infants is a typical and frequently occurrence of a physiological jaundice extension. Breast feeding and jaundice are strongly linked in healthy newborn newborns. Aim of the work: This study aimed to improve outcome of neonates with idiopathic hyperbilirubinemia via doing comparison between breast-fed and artificial-fed infants with idiopathic hyperbilirubinemia. Patients and methods: Our study included 150 neonates diagnosed with hyperbilirubinemia attending to Suez Canal University Hospital's Neonatal Intensive Care Unit. They were divided into group one included 50 neonates who received 75% of their feed as breast milk, group two included 50 neonates who received 75% of their feed as formula feeding (FF) and group three include 50 neonates who received both formula and breast feeding. Each neonate was subjected to complete history taking and examination. Results: The mean serum bilirubin was higher among breast-fed infants than formula-fed infants at admission and after 2 days with statistically significant difference. Feeding frequency showed statistically significant weak negative correlation with bilirubin among formula-fed infants. Statistically significant negative correlation between bilirubin change after 2 days of admission in formula-fed infants and weight with bilirubin change among formula-fed infants. Conclusion: Breastfeeding jaundice should be considered one of the most common causes of pathological jaundice, making lactational counseling throughout the antenatal and postnatal period to be an essential component of pathological jaundice care and prevention.