Background: Both diabetes mellitus (DM) and ankle fractures are becoming more common. Patients who have both diabetes and an ankle fracture have a higher risk of complications, some of which can be fatal. Objective: The aim of the current study was to evaluate functional outcomes and complications of internal fixation of Pott's ankle fractures in diabetic patients. Patients and methods: During this prospective study, 30 patients with ankle Pott's fractures were recruited from Orthopedic Out-patient Clinic in Zagazig University Hospital, from January 2022 to January 2023. Operative fixation was done through Open Reduction Internal Fixation (ORIF) by plate and screws or tension band according to AO principles of periarticular fracture fixation. Results: The mean age of participants was 40.09 (SD 13.2) years and 60% were males. The high union rate occurs mainly at week 10 at higher percent (74%) in controlled diabetic patients, while union rate in uncontrolled diabetic patients was delayed till 6 months with higher complication rates. Conclusion: Both open and closed therapy of ankle fractures are associated with greater complication rates in patients with DM. Patients with poorly controlled diabetes who have high HBA1C levels experience more complications than patients with well-controlled diabetes. The best method of treating unstable ankle fractures in diabetes patients under control is open reduction and internal fixation.