Background: The most frequent gynecological tumors in women are uterine fibroids. The purpose of this study is to determine the prevalence of fibroid among infertile women visiting an outpatient clinic for infertility and to investigate the effects of various myoma types on fertility. Patients and method: The infertility outpatient clinic, Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, was the site of this cross-sectional study. The study group consisted of 108 women, whose ages varied from 22 to 40 years and had uterine fibroids. Patients were examined thoroughly and transvaginal ultrasound examination was done for the assessment of pathological state and uterine fibroids (number, place, and size). Result: The uterus of 31.5% of infertile women contained numerous fibroid tumors. Patients with numerous fibroids had significantly higher odds ratio of being infertile (3.24, confidence interval: 1.28–7.24). Infertile women had a significantly higher percentage of intramural fibroid despite having a significantly lower percentage of sub-serous fibroid. According to the classification of The International Federation of Gynecology and Obstetrics (FIGO), 27.8% of the patients had FIGO 5, 28.7% had FIGO 6, and 7.6% had FIGO 7. Infertile women had a significantly greater percentage of FIGO classes 2 to 5. With odds ratio of 6.6 and a confidence range of 1.34 to 32.5, patients had a significantly increased risk of infertility based on FIGO 2–5. Conclusion: Though the significance of uterine fibroids is still up for debate, it would seem that myomas lessen the chance of conception.