Background: Gluten sensitivity leads to the inflammatory entropy known as celiac disease (CD), which develops in those who are susceptible to it. Some research has suggested a connection between childhood epilepsy and CD. Objective: The aim of the current study is to compare epileptic children and control as regard the development of gastrointestinal manifestations and gluten sensitivity. Patients and methods: A case-control study was conducted at Children's Hospital, Zagazig University. Children diagnosed with idiopathic epilepsy based on International League against Epilepsy 2017 classification had been included.The control group consists of 42 children, age and gender-matched with the case group.Medical history and complete physical examination were done for all children in both groups. Results: There is statistically a non-relationship between serum anti-tissue transglutaminase II (TTG) antibody and either number of drugs, control, presence of GI manifestations or duration of illness of the studied patients. Conclusion: It is important to pay more attention to the possibility of CD in children who are epileptic. To avoid irreversible problems, children with different idiopathic forms of epilepsy, and in particular children with frequent seizures, must be checked for silent CD.