Ten 1,5-2 year old, native ewes were used in the preset study. The disease was induced by feeding the ewes on deteriorated cabbage & turnip and straw pedding previously treated with ammonia. The diseased sheep displayed marked depression, changing appetite, mild to moderate recurrent tympany, dryness of the muzzle and intermittent diarrhea. Muscle tremors, nervous derangement, staggering and frequent recumbency were also evident. Ruminal atony and signs of abdominal discomfort were recorded in all cases. Values of hematocrit, BUN, SDH, GGT, ALK and AST were significantly elevated associated with reduced Cl level in the diseased sheep; Meanwhile the remaining blood biochemical Parameters showed non-significant variations from the base values. Changes in acid-base parameters (blood pH, HxCO3, TCO and PCO2) were evident and indicated that, metabolic alkalosis and respiratory compensation had taken Place, Biophysical and microscopical examinations of the rumen liquor were performed, and the effect of the disease condition on the rumen microbial ecosystem was recorded. Total counts of rumen protozoa, microbial activities and numbers of Entodinium species were significantly reduced. On the contrary, Isotricha recorded a significant elevation in the same animals. Other protozoal species showed non-significant changes from the base values. Ruminal fluid sodium and ammonia concentrations increased Significantly , while potassium concentration was significantly reduced in the same cases. Medical intervention had taken place, and complete recovery was evident.