A total of 120 birds (thirty from each of: ostrich “Struthio camelus", ducks “Anas plathyrhyn chus". Geese “Anser domesticus" and turkeys “Meleagris gallopavonis") were collected from different farms in Egypt and freshly slaughtered except ostrich samples were collected from ostrich slaughter house to detect antibiotic and sulphonamide residues in muscles (breast and thigh muscles), internal organs (liver, kidneys, gizzard) and fat after slaughtering. The samples were ex- amined by microbiological method (Agar diffusion test “inhibition test" by using cork borer) at pH 6.0 for detection of ß-lactum, tetracycline and penicillin residues, at pH 8.0 for detection of aminoglycoside residues, and at pH 7.2 was used for detection of sulpha drug residues. Positive samples for antibiotic and sulphonamide residues were reexamined after heat treatment (boiling for 30 minutes). The obtained data proved that the High incidence of antibiotic and sulphonamide residues in slaughtered ostrich, ducks, geese and turkeys were detected in kidneys and liver samples then followed by other tissues. Also, it was found that the highest numbers of positive samples for residues in these birds were observed at pH 6.0, then followed by those at pH 8.0 and 7.2 respectively. After boiling, the incidence of some antibiotic and sulphonamide residues decreased in some samples and completely disappeared in other samples. The judgment of the examined samples as well as the public health hazards of the antibiotic and sulphonamide residues were discussed.