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Fecal Microbiota Transplantation's Positive Effects on Ulcerative Colitis

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Microbiology and biotechnology

Abstract

Ulcerative colitis (UC) is a severe disease caused by immune system abnormalities leading to inflammation and ulcers in the large intestine. Dysregulation of gut microbiota is a key factor in UC. Fecal microbial transplantation (FMT) involves transferring fecal matter from a healthy donor to a recipient to alter gut microbiota and improve health. This study explored the effects of FMT on gut microbiome abundance and virulence genes in UC patients. Thirty metagenomic samples were retrieved from the NCBI database published under the project PRJNA768409. In that project samples were collected from three groups of participants. The first group is “Before" which includes patients with UC before administering FMT. The second group is “After" which includes patients with UC after administering FMT, after FMT and from donor participants. The third group is “donor" which includes healthy participant that gives their healthy feces for the “before" group. Results showed that 50% of the samples had decreased virulence genes, with reduced Actinobacteria and Bacteroidetes and increased Firmicutes after FMT. FMT significantly impacts UC patients, potentially reshaping the gut microbiome. Pre-FMT metagenomic analysis of donor samples is recommended to ensure safety.

DOI

10.21608/rpbs.2024.313596.1322

Keywords

ulcerative colitis, Fecal microbial transplantation, metagenomics, Virulent genes

Authors

First Name

Esraa

Last Name

Elsaeed

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt

Email

esraaelsaeed86@gmail.com

City

-

Orcid

0000-0003-3453-7490

First Name

Rasha

Last Name

Medhat

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt

Email

rashamedhat07@gmail.com

City

-

Orcid

-

First Name

Bassant

Last Name

Nour

MiddleName

-

Affiliation

Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Egypt

Email

bassantnor741421@gmail.com

City

Port Said

Orcid

-

First Name

Mostafa

Last Name

Hamed

MiddleName

-

Affiliation

Delta University for Science and Technology, Gamasa 11152, Egypt

Email

mostafahamed22.moalah55@gmail.com

City

Port Said

Orcid

-

First Name

Yasmeen

Last Name

Salama

MiddleName

-

Affiliation

Delta University for Science and Technology, Gamasa 11152, Egypt

Email

yassmensalama558@gmail.com

City

Port Said

Orcid

-

First Name

Engy

Last Name

Derbala

MiddleName

-

Affiliation

Delta University for Science and Technology, Gamasa 11152, Egypt

Email

engyderbala@yahoo.com

City

Port Said

Orcid

-

First Name

Magda

Last Name

Mourad

MiddleName

Magda

Affiliation

Delta University for Science and Technology, Gamasa 11152, Egypt

Email

magdamorad87@gmail.com

City

Port Said

Orcid

-

Volume

8

Article Issue

2

Related Issue

47568

Issue Date

2024-05-01

Receive Date

2024-08-19

Publish Date

2024-05-01

Page Start

157

Page End

166

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 8_Issue 2_Pages 157-166.pdf

PDF . 895.0kB

Link

https://rpbs.journals.ekb.eg/article_390271.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=390271

Order

390,271

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Fecal Microbiota Transplantation's Positive Effects on Ulcerative Colitis

Details

Type

Article

Created At

23 Dec 2024