Epilepsy carries an immense amount of suffering for both its young victims and their families. It has widespread direct and indirect effects on the child's Quality of Life [QOL. The aim of the present work was to assess QOL of school children with epilepsy and to investigate some of its determinants. In addition, perceived parental rearing styles, and maternal psychological morbidity of epileptic children were identified using case-control study design. Research subjects were 100 child-mother pairs of epileptic children recruited from the neuro-psychiatric outpatient clinic at the Student's Hospital in Alexandria. A matched control group for age and sex was recruited from the ENT clinic of the same hospital. The Parental Rearing Style Scale [PRSS], The Brief Arabic version of The Quality of Life in Epilepsy Questionnaire [QOLIE-14 items], and The General Health Questionnaire [GHQ] were applied. Results revealed that 13% of children with epilepsy experienced poor overall QOLIE, while 46% had moderate one. Major concerns of patients were mainly: seizure worry [65%], frequent difficulties with attention/ concentration [26%], and language [24%]. Though, 90% of subjects had good social support, yet more than 40% of them experienced social isolation and/or difficulties in social functioning. Emotional warmth and favoring subject were the parental rearing styles more significantly perceived by epileptic children compared to controls [t=2.69&5.69]. No significant differences were detected between cases and controls concerning maternal psychiatric morbidity. Logistic regression analysis indicated that parental rejection and control rearing styles, poor mother's psychological wellbeing, and low to moderate socio-economic status are significant predictors of poor QOLIE. Moreover, grand mal seizures, parental perception of child illness as very serious and extremely burdensome were significant predictors of maternal psychological ill health. The challenge for school health physicians is to incorporate QOL concepts into medical care of children with epilepsy to satisfy both patient and family needs.