This study was carried out to evaluate the kidney and liver functions as well as lipid profile in New Zealand rabbits fed on a diet containing contaminated plants grown through sewage water. Moreover, the beneficial effects of Propolis as a natural antioxidant for detoxification of sewage water hazards on rabbits' health was also studied. Nine male rabbits were randomly assigned into three experimental groups in which three rabbits were reared on sewage water and a basal plant diet grown in a pond containing sewage water for 14 days and were assigned as group 1 (G1). At the end of the experimental period blood samples were collected from the rabbits; centrifuged to separate their sera. The residual six rabbits were subdivided into two groups, three rabbits each. Group 2 (G 2) was reared on tap water and fed on a basal diet containing alfalfa for 35 days. Group 3 (G 3) was reared on tap water and fed on a basal diet containing alfalfa and Propolis for 35 days. At the end of the experiment period, blood samples were collected, and the sera were kept at -20°C for biochemical assay. Liver function (AST, ALT, ALP), kidney function (BU, Cr) and lipid profile (TC, TG, HDL, LDL) were investigated. Results showed that the AST, ALT, and ALP were within the normal values at the beginning of experiment. At the end of the 14 days intake, the liver enzymes significantly (p≤ 0.01) increased while, the results in the group (2) indicated that the AST, ALT, and ALP decreased, at the end of the experimental period (35 days from the beginning of the experiment). Regarding liver enzymes in group (3), the values were the lowest at the end of experimental periods (35 days). The BU and Cr in the group (1) the kidney indices reached the highest.  For group (2), the BU and Cr level lowered significantly (p≤ 0.01). However, group (3) the urea and creatinine reached the lowest value after 35 days. The concentrations of TC, TG, and LDL after one day were significantly (p≤ 0.01) increased. Meanwhile, HDL was lowered significantly (P≤ 0.01) after 14 days. Results of groups (2 and 3) the value of TC, TG. d LDL were significantly decreased (p≤ 0.01) at the end of experiment. While the level of HDL reached significantly to the highest value at the end of experiment. This study concluded that using contaminated plants grown through sewage water as a diet has adverse effects on animal and human health. Moreover, Propolis has beneficial effect as a natural antioxidant for detoxification of sewage water hazards on rabbits and human' health.
Keywords: Sewage water, Rabbits, Propolis, Kidney and Liver functions, Lipid profile.