Aim: The current study was performed to assess the changes in salivary pH in high caries risk patients using sodium fluoride mouth rinse and Miswak. Materials and Methods: a total of 20 patients were selected randomly according to inclusion and exclusion criteria. They were divided into 2 groups of ten patients each; (n=10). G1: used Miswak sticks, G2: rinsed with (0.05%) sodium fluoride mouth rinse. Patients used their corresponding interventions, for 2 minutes, twice per day for one month. Resting saliva samples were assembled at baseline and after one month. A quantitative method was used for measurement of salivary pH using pH meter. Data were analyzed statistically, and the significance level was set at p ≤0.05. Results: at baseline a higher mean value of salivary pH values was recorded in Miswak group (7.43±0.39) in comparison to Fluoride group (6.93±0.43). The difference between groups was statistically significant (p=0.014). After one month: a higher mean value was recorded in Miswak group (7.52±0.8) in comparison to Fluoride group (7.23±0.62). The difference between groups was not statistically significant (p=0.377). Conclusion: Both Miswak and sodium fluoride mouthwash reported impact positive effect by enhancing and maintaining the salivary PH.