This study investigated the effects of varying salinity levels on the growth and nutritional composition of the pangas catfish (Pangasius pangasius) over 60-day intervals. Fish seeds (25.3g) from Tawakal Fish Hatchery were acclimated and then exposed to four salinity treatment groups: T0 (0 ppt), T1 (2 ppt), T2 (4 ppt), and T3 (6 ppt). Parameters including salinity, temperature (26.2°C), pH (8.13), and dissolved oxygen (7.32mg/ L) were monitored daily. Fish were fed a commercial diet twice daily at 5% of their body weight. Significant differences in growth parameters were observed. Initial body weight remained consistent across treatments (P> 0.05), but final body weight decreased upon increasing salinity, with significant reductions in T2 and T3 compared to T0 (P < 0.01 and P < 0.001, respectively). Weight gain also significantly declined with higher salinity levels (P< 0.01), and feed conversion ratio increased with salinity (P< 0.01). Nutritional analysis revealed that crude protein decreased significantly with increasing salinity, while crude fat and ash content increased (P< 0.05 to P< 0.001). The study confirms that elevated salinity adversely affects growth and nutritional composition, with significant impacts indicated at higher salinity levels.