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388167

Efficacy of prophylactic use of hydrocortisone and low dose ketamine for prevention of shivering during spinal anesthesia

Article

Last updated: 31 Dec 2024

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Abstract

Background
Spinal anesthesia is commonly associated with shivering. The aim of this study was to compare the efficacy of i.v. hydrocortisone with i.v. low dose ketamine or placebo for prevention of shivering during spinal anesthesia.
Method
In this prospective, randomized, double-blind study, 90 female patients ASA I–II age 30–60 years old, undergoing posterior vaginal repair surgeries under spinal anesthesia with 3 ml heavy bupivacaine 0.5% (15 mg), patients were randomly allocated into one of three groups, (Group S,  = 30) (control) received saline, (Group K,  = 30) received ketamine 0.25 mg kg or (Group H,  = 30) received hydrocortisone 2 mg kg, the drugs were given i.v. just after spinal anesthesia with recording of vital signs, and core temperature every 15 min intraoperative and every 10 min in recovery room. The incidence and intensity of shivering, number of patients received meperidine, sensory level, motor block grade, and side effects (hypotension, hypertension, tachycardia, nausea and vomiting, sedation and hallucinations) were also recorded.
Results
Incidence of shivering were significantly reduced in k and H groups being 20% and 23.3% respectively compared to S group ( < 0.05). Patients received meperidine to control shivering were significantly low in Groups K and H compared to group S ( < 0.05), with no difference between Groups K and H.
Conclusions
The prophylactic administration of low dose ketamine (0.25 mg kg) and hydrocortisone (2 mg kg) were comparable in reducing the incidence of shivering and both had significant antishivering effect compared to placebo, in female patients under spinal anesthesia for posterior vaginal repair surgeries.

DOI

10.1016/j.egja.2012.04.002

Keywords

Spinal anesthesia, Ketamine, Hydrocortisone, shivering

Authors

First Name

Ashraf Abd

Last Name

Elmawgood

MiddleName

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Affiliation

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City

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Orcid

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First Name

Samaa

Last Name

Rashwan

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Doaa

Last Name

Rashwan

MiddleName

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Affiliation

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Email

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City

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Orcid

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Volume

28

Article Issue

3

Related Issue

51176

Issue Date

2012-07-01

Receive Date

2012-02-06

Publish Date

2012-07-01

Page Start

217

Page End

221

Print ISSN

1110-1849

Online ISSN

1687-1804

Link

https://egja.journals.ekb.eg/article_388167.html

Detail API

https://egja.journals.ekb.eg/service?article_code=388167

Order

388,167

Publication Type

Journal

Publication Title

Egyptian Journal of Anaesthesia

Publication Link

https://egja.journals.ekb.eg/

MainTitle

Efficacy of prophylactic use of hydrocortisone and low dose ketamine for prevention of shivering during spinal anesthesia

Details

Type

Article

Created At

21 Dec 2024