Background: Developing self-management skills is one of the most important activities for first-line nurse managers who aim to become more productive not only at work, but also in their personal lives. The study aimed to assess first-line nurse managers' perception regarding self-management knowledge and skills. Design: A descriptive correlational design was utilized. Setting: The study was conducted in all inpatient units of the medical and surgical buildings at Benha University Hospital. Subjects: Convenient sample of all (77) first line nurse managers during data collection. Tools: two tools were used for data collection namely; Self- management knowledge questionnaire and self-report regarding self- management skills. Results: showed that majority of first line nurse managers (92.2%) had poor perception level regarding self-management knowledge and the majority of first line nurse managers and their assistant (85.7%) had in adequate perception level regarding self-management skills. The study concluded that there was no statistically significant correlation among first-line nurse managers' knowledge, and skills regarding self-management. The study recommended: Focusing on self-management skills by using the critical thinking technique to develop first line nurse managers' skills and abilities in a different management role