Background: Hysterectomy is the removal of the uterus and it is the commonest major surgical procedure after caesarean section performed in gynecology. Aim: This study aimed to examine women's knowledge and self-care practices post hysterectomy surgery. Methodology; Design: Descriptive study. Participants: 60 women undergoing hysterectomy at a hospital in Egypt. Data Collection: Three tools: (I) Structured interview questionnaire, (II) Self-reported knowledge questionnaire, and (III) Self-reported practice questionnaire. Key findings: Knowledge: 88.3% of women had inadequate knowledge about self-care after hysterectomy. Practices: 98.3% of women reported unsatisfactory self-care practices post-surgery. Demographics: Average age: 46.4 years, literacy rate: 30%, marital status: 75% married, parity: 71.7% with 4+ children, and reason for surgery: 48.3% abnormal uterine bleeding. Conclusion: Most women lacked sufficient knowledge and practiced unsatisfactory self-care after hysterectomy. Recommendation: Implement a structured discharge plan with pre- and post-operative education on self-care practices to prevent complications.