Background: Palliative care entails providing parents and children with cancer with comprehensive, skillful, and compassionate care. Aim of the Study: assess of nurses' attitude and practice toward palliative care for children with cancer. Research design: A descriptive design; a purposive sample consisted of sixty-five nurses who were providing palliative care for children with cancer. Setting: This study was conducted in pediatric unit at Children's Hospital affiliated to unit of Oncology Children at Menoufiya University Hospital and Ain Shams University Children's Hospital. Data collected through using three tools including: I: Interviewer questionnaire which consisted of 2 parts: Part1: Nurses' socio demographic characteristics. Part2: nurses' attitude level. II: observational checklists. III: performance palliative scale. Results: There was significant relationship between studied nurses' total attitude and their total practice regarding palliative care for children with cancer (P<0.05). Conclusion: Most of the studied nurses have a good attitude and majority of them have competent practice about palliative care for children with cancer. Recommendations: Study was recommended that adopting a suitable assessment tools for early detection any health problems for children with cancer to enhance their quality of life should be applied.