Background: Behçet's disease (BD) is characterized by inflammation of the arterial and venous walls throughout the body and has an unknown cause. Objective: This study was aimed to assess articular involvement in patients with Behçet's disease: a pilot study with bone scintigraphy. Patients and Methods: This study included a total of 25 Behçet's disease patients, attending at Departments of Radiodiagnostics and Nuclear Medicine, Cairo University Hospitals. They were subjected to the following: Full history taking, clinical examination, routine laboratory tests including CBC, ESR, CRP and conventional radiological examination and bone scintigraphy in the radiodiagnosis and the nuclear medicine departments respectively, Cairo University Hospital. Skin pathergy test was performed. Results: Joint involvement was clinically apparent in 12 of the 25 cases (48%). Two individuals (8 percent) had signs of rheumatoid arthritis in their hands. The most frequently involved site on bone scintigraphy was the wrist (100%). All of the patients (100%) revealed hand scintigraphic involvement, 24% of them had mild score, 60% had moderate score and 16% had severe score. Conclusion: It could be concluded that bone scintigraphy is helpful in identifying articular involvement and pinpointing its location.