Carbimazole drug is used to induce hypothyroidism in the animal model. Hypothyroidism indicates disturbances of the liver and kidney functions. Several trials of treatment the hypothyroidism either by synthetic drugs or natural products were conducted in recent years. Concomitantly, this work was conducted to evaluate the effects of levothyroxine as a drug used for the treatment of thyroid hormones deficiency (hypothyroidism) and bradykinin potentiating factor (BPF) separated from honey bee venoms, Apis mellifera on the liver and kidney functions in a model of hypothyroid male rats in comparative mannar. The results revealed that, hypothyroid group significantly raised plasma total and direct bilirubin, ALT, AST, total protein, albumin, urea, uric acid and creatinine levels. Also, histological observations of the liver and kidney tissues in hypothyroidic male rats showed different abnormalities in these organs. Moreover, PAS stained liver and kidney sections revealed a decrease in polysaccharides in carbimazole treated group compared to control group. Treated animals with levothyroxine or BPF and carbimazole co-treated groups with either levothyroxine or BPF improved the negative effects or complication of hypothyroidism on the male rat's liver and kidney at the level of biochemical and histological studies.Levothyroxine as a drug and BPF as natural product revealed nearly similar improvement in this study. In addition, BPF ameliorating the deleterious effects of hypothyroidism possibly by the direct effect of this factor, stimulate the synthesis of T3, T4, growth hormones and endogenous bradykinin.