Background: Burn is the most important cause of child injury that leads to serious health problems, severe social functional and psychological impairment. Burn is the major cause of hospitalization and association with significant morbidity and mortality. Aim: The present study aimed to assess nurses' knowledge and practice regarding burn in children. Design:  A correlational descriptive study was utilized. Setting: The study was carried out at Burn Units affiliated to Suez Canal University and Ismailia General Hospitals. Sample: A convenience sample of nurses (35) was working at the previous mentioned settings and 20 children suffering from burn injury during the study period. Tools of data collection: a structured interview questionnaire, and observational checklists to assess Nurses' knowledge and practices regarding burn in children. Results: The study results revealed that less than half of the studied nurses had poor knowledge and most of them had unsatisfactory practice regarding burn in children. Conclusion: There was no a significant correlation between the studied nurses' total knowledge and their total practices regarding burn in children. Recommendations: The study suggested nursing intervention program regarding management of burn in children based on their actual need assessment.