Background: Cerebrovascular stroke is a worldwide main concern and a leading cause of disability. It is one of the major health problems associated with complex neurological needs which increased the need for competent nursing care. Nurses working in stroke care units require multifaceted competence. Nurses frequently are the health care professionals who see the full impact of CVS and should have the skills that can faster the course of patient's recovery. Therefore, nurses need to have valuable knowledge, competent skills, and a positive attitude to help patients with stroke to achieve the best possible outcomes. Objective: To evaluate the effect of a competency-based program on nurses' knowledge, skills, and attitude toward the care of patients with stroke. Settings: The study was conducted at the Neurological Department and Stroke Center at El Hadara University Hospital and at the Neurological Department at El Nozha Hospital for Neurological and Psychiatric Diseases. Subjects: All the neurological nurses available at the time of data collection, about (n=50) from the above-mentioned settings who were providing direct care for patients with stroke. Tools: Three tools were used to collect data for this study, Tool I: Nurses' Knowledge of Stroke Questionnaire, Tool II: Nurses' Skills Competency Level Observational Checklist, Tool III: Nurses' Attitudes towards Patients with Stroke Questionnaire. Results: the study revealed highly statistical significant improvements in the studied nurse's knowledge, skill competencies and attitudes throughout the intervention periods of the study from pre, immediate, and two months after the implementation of the competency-based program. A slight decline was found in knowledge, and skills scores in the third assessment as compared to the second assessment time. Conclusion: the current study revealed the effectiveness of the competency-based program where nurses' knowledge, skills and attitudes, improved significantly as compared before implementing the program. Recommendations: Development and application of periodic educational and training courses for stroke unit nurses regarding the comprehensive care of stroke, to equip them with the sufficient knowledge and competencies essential for providing high quality care for patients.