Background: Enteral feeding is the prioritized method of administrating nutrients in high-risk neonates. The current study aims to assess nurses' knowledge and practices toward enteral feeding and its effect on selected high-risk neonates' outcomes. Subjects and Method: A descriptive exploratory research design was conducted in Neonatal intensive care unit at Beni-Suef University and general Hospitals in Beni-Suef city, Egypt. A purposeful sample of neonatal pediatric nurses responsible for providing direct care for high-risk neonates (70 nurses) at Beni-Suef University and general hospitals during data collection and neonates were utilized in this study. Three data collection tools were utilized in this study: Tool I: Nurses' knowledge questionnaire, Tool II: Nurses practice checklist, and Tool III: neonatal outcomes. Results: nearly two-thirds and nearly half of the studied nurses had unsatisfactory knowledge and practice regarding enteral feeding of high-risk neonates. Also, moderate effect between acute increase of abdominal girth after 2 hours in the 3^rd day of the study with nurses' knowledge and practice toward enteral feeding of high-risk neonates and hospital duration of high-risk neonates at the 3^rd and 4^th days of the study with nurses' practice. Conclusion: nurses' knowledge and practices about enteral feeding of high-risk neonates had a moderate effect on the acute increase of abdominal girth after 2 hours in the 3^rd day. Recommendation: periodically implementing of health education training toward enteral feeding high-risk neonates to enhance their knowledge and practices and reduce effects on high-risk neonates' outcomes.