Background: Improving the quality of abortion care may lead to reductions of abortion-related morbidities and mortality. Aim: this study aimed to evaluate effectiveness of implementing Evidence Based Practices Guideline on nurses' performance regarding caring of aborted women. Subjects and Methods: Quasi experimental research design (one group pre-test, post-test) was utilized to fulfill the aim of this study. Setting: this study was conducted in obstetrics, labor and gynecological departments at Minia university hospital for maternity and child. Sample: convenient sample included 55 nurses. Tools: two tools were used: A self-administered Questionnaire and Practical observational checklist. Results: The main findings of the study revealed that 72.7% of the studied nurses had poor knowledge regarding abortion and 87.3 % of them had unsatisfactory level of practice regarding caring of aborted women in pretest. Meanwhile after application of evidence based guidelines it was observed that there was a highly significant improvement in their knowledge and their practice regarding abortion care compared to pretest (P-value ≤ 0.0001). Conclusion: The implementation of an evidence based guidelines was effective and significantly improve nurse's performance regarding caring of aborted women. Recommendation: This study recommended that: Strategies for continuous improvement of nurse's knowledge and practice about evidence based abortion care should be developed in obstetrics department such as regular training courses, Special standardized procedures booklets