Background:  Severe iodine deficiency during pregnancy is still a leading cause of maternal and fetal hypothyroidism, as well as preventable cognitive damage, all over the world. The aim of the study is to Assess of Pregnant Women's Knowledge and Practice about Risks of Iodine Intake Deficiency during Pregnancy. Research Design: A descriptive study design was utilized to attain the aim of this study. Subject and setting: Convenient sample (300) pregnant women who visited the general hospital in Mallawy district at Mania governorate in Egypt at the outpatient antenatal clinic over period (6) month. Tool of data collection: Structured interview questionnaire include (3 parts) (socio-demographic characteristics, pregnant women knowledge regarding iodine intake deficiency during pregnancy and pregnant women practice regarding iodine intake during pregnancy) Results: The study demonstrates (64.7%)of the studied women have unsatisfactory knowledge about iodine intake during pregnancy.(68%) of the studied women have unsatisfactory practice about iodine salt intake during pregnancy, with a high statically significance relationship between total level of knowledge and total practice about iodine salt intake during pregnancy. Conclusion: This study concluded that around two-thirds of pregnant women knowledge and practice towards iodine salt intake deficiency during pregnancy were unsatisfactory with highly statistically significant relationship between women knowledge and practice towards iodine salt intake deficiency during pregnancy. Recommendation: Educative programs to increase awareness on iodine are very important challenges for Egyptian pregnant women, in the coming years