Background:  Eclampsia proceeds to be a major problem in pregnant and post-partum women. Maternity nurses can play a major role in prevention of maternal deaths related to eclampsia. Aim of the study: to assess nurses' knowledge and practice regarding management of Eclamptic women at obstetric, gynecological and child minia university and general minia hospitals. Research design: A descriptive research design was utilized in the present study. Sample: A total of 78 female nurses recruited at convenience which classified as 60 nurse who work in obstetric, gynecological and child minia university hospital and 18 nurses who work in general mina hospital. Tool of data collection: a structured interview questionnaire which included three parts:1: personal and Socio demographic data part 2: nurses' knowledge about eclampsia and it is management part3: observational checklist Results: The findings of this study revealed that, more than half of the study sample (53.2%) had good knowledge and near to two-third (64.9%) had poor practice / skills level in managing eclampsia. There was statistically significance different in nurse's knowledge working in Obstetric & Gynecological and Child Minia University Hospital and Minia General Hospital  (p =002) while, there were not statistically significance differences between nurse's practices in these two hospital Conclusion: The study concluded that there were a gaps between knowledge and practice in the area of managing women with eclampsia. Recommendations: Regular training programs to encourage nurses to update and improve their practice.