Background: Although the use of laparoscopy has gradually gained favor, the short-term benefits generally observed with laparoscopy applied to patients undergoing partial hepatic resection remains unclear. The aim of the present study was to report and compare the results of patients undergoing laparoscopic hepatectomy (LH) and open hepatectomy (OH) in short term follow up. Patients and methods: This is a controlled randomized prospective study conducted in Ain Shams University Hospitals between December 2012 and April 2015 comparing laparoscopic non-anatomic hepatectomy (15 patients) and open non-anatomic hepatectomy (15 patients) in the management of HCC in cirrhotic patients. Results: There were no significant differences between both groups regarding operative time (145 ±43 min Vs 152 ±49.92 min P =0.679), blood loss (376 ±250ml Vs 526 ±307 ml P =0.156). Overall complication rate (46.7% Vs 53.3% P =0.715), post-operative ascitis (P =0.156) and overall thirty day mortality (0% Vs 6.7% P =0.31). Safety margin was adequate in both groups. Hospital stay was significantly lower in the group of LH (9.8 ±3.76 days) than in the group of OH (15 ± 4.76 days) (P = 0.001). Conclusion: Laparoscopic non-anatomical hepatectomy for HCC in cirrhotic liver is equally safe and feasible in segments II to VI.