Introduction: MELD  score was validated  as a predictor of mortality  for a wide variety of liver diseases,8 including  cirrhotic  patients  awaiting  liver  transplantation  (LT).9 we try  to assess the impact  of MELD  score on patient survival and morbidity  post living donor liver transplantation (LDLT) . Design: Retrospective study. Methodology:  Between February  2007 and December  2011, 80 adults patients,  randomly selected with ESLD, had living donor liver transplantation. Nine patients were excluded,  the remaining 71 patients were divided into two groups. Group 1 included 38 patients with MELD < 20. Group 2 included  33 patients with MELD  > 20. We compared both  groups as regard operative data (including operative time and intra-operative blood requirement), early post­ operative course (including JCU stay, hospital stay, incidence of infection and other morbidity like renal impairment, cardiovascular, respiratory and neurological complications) and patient survival up to 1 July 2012. Results: Eleven patients died during this study (15.2%):  three out of 38 patients (7.8%) in group 1 and 8 outof33 patients (24.2%) [P=0.02]. Mean  hospital stay was 30±14 and 29±18 days in 1st and 2nd group respectively [P=0.937]. The mean JCU stay in group 1 and 2 was 7±3 and 9± 4  days [P=0.315]. Mean operative time in group 1 and 2 was 11.1±2 and 10.6±1.4 hours [P=0.292]. Mean  volume of blood transfusion  and cellsaver  re-transfusion  were 8±4 unit and 1668±202 ml respectively in group 1 in comparison to 10±6 unit and 1910±679  ml respectively  in group 2 [ P  =  0.09 and 0.167].  The incidence  of infection  was 39.4%  and 45.4% in group 1 and 2 respectively [P=0.48]. The incidence of systemic complications (renal, respiratory, cardiovascular and neurological complications) in group 1 and 2 were 36.8% and 45.5% [P =0.3] Conclusion: MELD  score more than 20 can predict poor overall survival post living donor liver transplantation.  No significant relation between MELD  score and intra-operative  blood requirement, hospital, and JCU stay or post LDLT morbidity was noted.