of investigation, 92 cases of the clinically examined During the period buffaloes (2237) showed signs of mange due Psoroptes bovis infection. The clinical signs of the infected buffaloes were described. There was no (p>0.05) between female (4.13 %) and Males (4.05 %) significant variation buffaloes. The percentage of infection with buffaloes' psoroptic mange was increased with increasing the age of animals till two years old. Thereafter this percentage was decreased with increasing the age of animals. The minimum percentage of infection was recorded among buffaloes over six years old. From ecological point of view, there was no significant variation (p>0.05) in the percentages of infection with psoroptic mange in buffaloes, which bred in the southern or the northern villages of Assiut Governorate. According to the nature of land, the percentage of infection with psoroptic mange of buffaloes, bred in semi-desert villages was highly significantly increased (p < 0.01) than those of buffaloes, which bred in cultivated villages. The maximum percentage of infection with the disease was noticed during the winter and autumn seasons. Conversely, the percentage of infection was minimum during the summer season. Ivermectin was effective, of easily administration and practicable particularly in heavily infected cases and in the large numbers. Otherwise application of sulphur ointment on the affected areas is considered more and more economical in comparison with Ivermectin. The psoroptic mange of buffaloes is probably considered as "adaptational disease" depends on the environmental factors that enhancing the infection.