Forty eight of weanling New Zealand White (NZW) male rabbits of 5 weeks old and  averaged 488 g body weight were used to evaluate the negative effects of adding aluminum (Al) in diet on growth performance, blood haematological and immunological indices, plasma biochemical constituents and accumulation of Al in some organ tissues. Animals were divided randomly into 4 groups. The first group fed on control diet while the second, third and fourth groups were fed on the control diet mixed with Al sulfate to perform three added levels of Al, 1000 (T1), 2000 (T2) and 3000 (T3) ppm. The results showed reduction (P<0.001) in averages of final body weight and daily weight gain for T1, T2 and T3 groups when compared to control one. Averages of feed intake decreased (P<0.05) in T3 group of rabbits compared to control. T1, T2 and T3 groups of male rabbits showed lower (P<0.001) feed conversion efficiency than the control one. Blood Hb concentrations, RBCs count per mm³ blood and PCV % were lowered (P<0.01) for T2 and T3 rabbits than control. Total count of leucocytes increased (P<0.01) for T2 and T3 rabbits when compared to control. Rabbits of T2 and T3 had lower (P<0.01) lymphocytes % and higher (P<0.01) neutrophils and eosinophils % than control. There were decreases (P<0.01) in concentrations of plasma total protein and globulin for T3 rabbits, and in plasma glucose of the treated rabbits when compared to control. Plasma cholesterol increased (P<0.01) for T2 and T3 rabbits compared to control. Rabbits of T1, T2 and T3 groups had lower (P<0.01) concentrations of thyroid hormone (T₃) than control. Plasma Al concentrations increased (P<0.01) for T1, T2 and T3 rabbits compared to control. Al accumulation increased (P<0.01) in muscles and livers of T2 and T3 rabbits compared to control while it was highly accumulated (P<0.01) in kidneys and brains of the treated groups. This study indicated that adding Al, especially at 2000 and 3000 ppm, adversely reduced growth performance and metabolic activities of male rabbits as a result of the negative effect of Al on their physiological reactions as shown from the obtained results