A pot experiment was carried out under greenhouse conditions to test the reaction of different wheat genotypes to salt stress. The seeds of 15 wheat genotypes were grown in pots containing sandy loam soil and later on the seedlings were subjected to 3 levels of saline irrigation water after 2 weeks of seed germination. The selected wheat cultivars included Shakha 93, Sakha 94, Misr1, Sids1, Sids12, Sids13, Giza168, Giza171, Sahel 1, Shandawil 1, Gemmiza 7, Gemmiza 9, Gemmiza 10, Gemmiza 11 and Gemmiza 12. The salinity of irrigation water was prepared by dissolving an appropriate amount of NaCl in tap water and adjusted to give 4500 and 8500 mg/l, beside the control treatment of tap water (500 mg/l). After 5 months of saline water application, the plants were harvested, whereas plant growth indices, grain and straw yields, as well as the harvest index were recorded. The results have shown that plant growth characteristics and yield potentials were significantly suppressed with increasing the salinity stress levels, but the rate of decline varied considerably among all trails. The more serious effect of the salinity exposure was manifested on grain yield, being 39.8 and 54.5% at 4500 and 8500 mg/l, respectively. Wheat genotypes, namely Gemmiza 7, Gemmiza 9 and Sids 1 were more superior in grain yield performance, even at the highest concentration level of irrigation water. Unlike, Gemmiza 11, 12;  Misr 1,  Sakha 94, Giza 168, 171, Shandweel 1 and Sids 12, 13 were reacted as the more salt-sensitive cultivars. The remaining genotypes were intermediate in reaction. On the evaluation and screening wheat cultivars to salt stress, the simple regression equation of the type y=a + b  was considered to give a better expression for the quantitative assessment.  According to our calculations, genotypes, i.e. Gemmiza 7, Gemmiza 9 and Sids1 were classified as salt tolerant cultivars and Sakha93, Sahel 1 & Gemmiza 10 as moderately salt tolerant and the remaining cultivars showed higher sensitivity to salt tolerance.  It could be concluded that the more salt tolerant varieties could be used as a valuable cultivars in breeding programs under salt-stressed condition.