Abstract The main target of the present investigation was to study the effect of some calcium sources on the level of Lead in albino rats. Thirty healthy adult male albino rats "Sprague Dawley strain" weighing 150±5g , were used and divided into 6 equal groups, one was kept as a negative control group, while the second Group(5rats)  fed on basal diet with lead 0.7%( control positive group),  group (3 and 4 )  was fed basal diet with lead and calcium chloride 0.5% and 1% respectively (as chemical calcium source) ,while groups (5 and 6 )  was fed on diet with lead 0.7% and Molokia leaves at 5% and 10% respectively for 28 days. At the end of the experiment, feed intake (FI), body weight gain (BWG), feed efficiency ratio (FER) and relative weights of liver, kidneys and spleen were calculated. Also, serum liver functions (GOT & GPT) and kidney functions (Urea & CR) were determined in serum. Histopathological changes of liver  were examined. The results indicated that rats infected lead which fed on diet with calcium cholride and molokia leaves  significant increase in body weight gain, feed intake and feed efficiency and improved the liver functions and  kidney functions when compared with positive control. Treating rats with calcium sources especially natural source at 10% and calcium cholride at the level 1% decreased the toxic effect of lead in rats body on tested parameters. Also, they decreased the toxic changes in cell structure of liver when compared with liver's tissues of positive control.