Objective: To evaluate, both radiographically and histologically, the efficacy of platelet rich fibrin versus collagen cone as socket preservation materials. Materials and methods: Fifteen patients with 21 non-restorable maxillary anterior or premolar teeth were divided into 3 equal groups. In group 1, extraction sockets were preserved with platelet rich fibrin, and in group 2 with collagen cones. Group 3 acted as control. A CBCT images were obtained immediately post-extraction as well as 3 months later. The CBCT images were superimposed and the vertical and horizontal bone losses were calculated accordingly. A trephine bur was used to collect bone specimens from the preserved sockets after 3 months for histological evaluation. Results: No statistical significant difference could be found between the 3 groups radiographically. Histological examination revealed a denser bone with organized bone trabeculae and less bone marrow spaces in group 1 compared to group 2 and 3. Conclusions: PRF can of accelerating new bone growth in extraction sockets. However, neither PRF nor collagen cone can preserve alveolar bone dimensions following tooth extraction.