Objective:The aim of the current study wasto evaluate and compare the effect of the effect of endodontic irrigants on the micro-tensile bond strength and hybrid layer of self-etch and universal adhesives to dentin Materials and Methods:forty-eight teeth were collected and their occlusal surfaces were flattened until middle dentin was exposed. They were divided into four groups according to surface treatment of dentin(untreated (control), sodium hypochloride, ethylenediaminetetraacetic acid and combination of the two irrigants).two different adhesives were selected for the current study (one bottle self-etch adhesive and universal adhesive). After surface treatment, adhesives were applied according to manufacturers' instructions. After bonding, composite restoration (tetric N-ceram) was built up incrementally. Resin/dentin specimens were sectioned for micro-tensile bond strength (µTBS) testing. A specimen from each group was randomly selected and investigated under scanning electron microscope (SEM). Results: Significant differences were observed among the adhesives (p < 0.01). In self-etch groups, all irrigants variables were significantly different to control. EDTA was not significantly different to NaOCL. While, its combination with NaOCL was significantly different to NaOCL. The combination of both irrigants was not significantly different to EDTA. In universal groups, all irrigants variables were significantly different to control. Both EDTA and its combination with NaOCL were significantly different to NaOCL. The combination of both irrigants was significantly different to EDTA. Conclusions: The use of a combination of sodium hypochloride andethylenediaminetetraacetic acid as a regular endodontic irrigant in dental clinic was found to enhance the bond strength between dentin and both the self-etch and universal adhesives used to bond the coronal composite restoration. Keywords: Sodiumhypochloride, Ethylenediaminetetraacetic acid, one-step self-etch adhesive, universal adhesive, micro-tensile bond strength