Background: Hysterectomy is the most common gynecological surgery in the world in which uterus is removed surgically partially or totally through vaginal, abdominal or laparoscopic routes. Aim of study: Was to evaluate effect of Roy's Adaptation Model on sexual function for women after total hysterectomy. Study design: A quasi-experimental study design (pre & post-test design) was utilized to fulfill the aim of this study. Setting: The study was conducted at Obstetric and Gynecological department and the outpatient clinics in Benha University Hospital. Sample: A purposive sample of 80 women who undergo hysterectomy, chosen according to the main inclusion criteria (married with active sexual relationship and           don't use drugs that affect the sexual health) and divided randomly into control group comprised (40) women and study group comprised (40) women. Tools of data collection:  Four tools were utilized, I: Self-administered questionnaire, II:Female sexual function index (desire, arousal, lubrication, orgasm, satisfaction and pain), III: Roy's Adaptation Model Scale (physiologic, self-concept, role function and interdependence mode) and IV: Woman's satisfaction scale. Results: Almost two thirds of study group were highly satisfied of Roy's Adaptation Model. Total Roy's Adaptation Model improved from tenth at pre intervention phase to more than three fifths at post intervention phase among study group while there was no improvement in the control group. More than three fifths of study group had good knowledge score about hysterectomy at post intervention phase compared to only one quarter of control group. There was a highly positive significant correlation between total knowledge score and total score of sexual function and adaptation in study group at post intervention phase. Conclusion: Application of Roy's Adaptation Model had a positive effect on sexual function for women after total hysterectomy, therefore, the study hypothesis was supported. Recommendation: Increasing women sexual awareness after hysterectomy through distributing a simplified and comprehensive booklet and posters in all gynecological settings which include a clear, brief and simple explanation about post-hysterectomy sexual life to reduce hysterectomy related sexual problems.