Background: Pacemaker is the recommended therapy for treating the conduction system disorders. Aim of this study:  Was to evaluatetheeffectiveness of an educational program for management of patients undergoing permanent pacemaker on nurses' performance.Design: Quasi experimental design was utilized. Setting: This study was conducted in the Coronary Care Unit and Cardiac Catheterization Unit at Benha university hospital.  Sample: All available nurses were included (42) nurses. Data collection tools: Two toolswere used, I: A structural interview to assess studied nurses' demographic characteristics and knowledge about nursing management of patients undergoing permanent pacemaker and II: Observational checklist to observe nurses' practice about nursing management of patients undergoing permanent pacemaker. Results: Two thirds of nurses had poor total knowledge pre-program implementation whenever, more than two thirds of nurses had a good total knowledge post-program implementation and more than half of them had a good total knowledge on follow-up post program implementation. The majority  of studied nurses had un satisfactory level of practice pre-program implementation whenever, nearly two thirds of them had a satisfactory level of practice post-program implementation and more than half of them had a satisfactory total practice follow-up program implementation.Conclusion: A statistically significant improvement in nurses' knowledge and practice immediately and after two months compared to their baseline assessment. Recommendation: Continuous educational programs for nurses based on evidence to improve their knowledge and practice related to pacemaker.