Hybrid air conditioning systems can allow significant energy saving and emissions reductions with respect to conventional air-conditioning systems. Thermal analysis of a desiccant wheel, a heat exchanger, a ground source circulation system, and a solar collector for a hybrid air conditioning system is performed in this study. The effects of these parameters have been studied: Inlet air temperature, Inlet air humidity ratio, wheel speed, regeneration temperature, regeneration mass flowrate, heat exchanger effectiveness, ground source circulation effectiveness, and solar radiation on the behavior of the outlet air temperature and the outlet air humidity ratio from the desiccant wheel, the area of solar air collector, the solar collector efficiency, the cooling coil load, and the coefficient of performance. The hybrid system is more efficient than the vapor compression system. The hybrid system significantly decreases the cooling coil load, the cooling coil load of the hybrid system is approximately 48 % lower than the vapor compression system.