Background: Resistance to tuberculosis (TB) drugs is a formidable obstacle to effective TB care and prevention globally.
Patients and Method: This study included 100 patients of both sexes were chosen from outpatient clinic and inpatient word in Qena University hospital. Patients were subjected to: Full history and examination, chest X-Ray, ESR, CBC, sputum microscopic examination, Genexpert for sputum samples, sputum cultures.
Results: : Patients with treatment failure were 64 with mean age 48.9±16.1 and 34.4% of patients were male and 65.6% females. The mean ESR in was 1ST hr 101 and after 2nd hr 120. About 43.8% stopped working and 38.5% borrowed money. Chest x-ray showed 50.1% cavitary lesion, 21.8% consolidation, and 28.1% miliary shadow. Patients with treatment response were 36 with mean age 57.3±19.3, about 55.6% of them males and 44.4% females. The mean ESR 1ST hr 54±24, 2ndhr 96.1±32.Chest x-ray showed 22.2% cavitary lesion, 44.4%consolidation and 33.4% miliary shadow. About 38.9% stopped working and 55.6% borrowed money.

Conclusion: This study showed increase social and economic burden in TB resistant patients. We noticed that TB resistant patients were reported income loss and work affection.