Background: Nursing interns must improve their nursing decision making ability and utilize it in their daily practice. The Purpose of the study was to assess nursing interns' decision making ability and its relation with self- esteem. Design: A descriptive correlational research design was utilized to conduct this study. Sampling: All available nursing interns (420) who were enrolled in internship year within the academic year 2020-2021 were included. Setting: It was conducted at different departments and units at selected hospital at Shebin. Elkom. This hospitals Namely Menoufia University Hospital, Shebin Elkom Teaching Hospital, El Helal Health Insurance Hospital and national liver institute hospitalOperation room ,intensive care units, hemodialysis units and departments Instrument: clinical decision making ability questionnaire and self -esteem questionnaire was used for data collection. Results: Showed that more than half of nursing interns (63.8%) had decision making ability, while more than one third (36.2%) did not have decision making ability. More than two third (71%) had moderate level of self -esteem .Conclusion: there was a highly statistical significant positive correlation between student's level of Decision-Making Ability and self-esteem Recommendation: hospitals should provide adequate training programs to improve nursing interns' student's Decision-Making Ability and self-esteem.