Background: Hepatitis C virus (HCV) is a disease of significant global impact, every family in Egypt is touched by hepatitis C virus infection, this blood borne virus which is highly infectious. The aim of study: to assess the hepatitis C virus patients' adherence to infection control precautions at homes Materials and methods: A cross sectional design was utilized in this study; the study was conducted at the outpatient clinics in El-Salam International Hospital affiliated to Ministry of Health and Population at Mansoura City. The sampling method used was convenient sample included 430 hepatitis C virus patients who attended to outpatient clinic in El-Salam International Hospital affiliated to Ministry of Health and Population at Mansoura City to receive hepatitis C virus treatment. Tools: Three structured interviewing tools were used to assess socio-demographic and economic data, adherence of patients to infection control precautions at homes and factors that hinder the patients from adherence to infection control precautions at homes. The data were analyzed using SPSS (Stand for statistical product and service solutions) version 16.Results: revealed that there was highly statistical significance relationship between socio-demographic characteristics of patients and their adherence to infection control precautions at homes. Conclusion: Regarding patients' total adherence score to infection control precautions at home most of the patients were not adhered and more than one third of the patients did not do anything to adhere to infection control precautions at homes Recommendation: Providing Continuous educational programs for patients and their families about hepatitis C to avoid complications of hepatitis C