Background For the last two decades, there have been concerns about the adequacy of clinical skills education of nursing students in terms of content and competency. Intramuscular injection (IM) is one of the common methods of drug administration technique. Administering an IM injection is a complex psychomotor task that requires skill and knowledge on the part of the healthcare professional that is performing the procedure. The aim of the present study is to assess adequacy of nursing students' knowledge, and skills about intramuscular injection. The study was conducted at Faculty of Nursing at Benha University. Descriptive design was used. Two tools were filled by 80 nursing students from first year from the above mentioned setting. (1) Knowledge questionnaire contains 23 questions and (2) Observation checklist contain 27 items about intramuscular injection .Results revealed that high percent (80%&70%) of nursing students have adequate skills and knowledge about intramuscular. There is positive significant correlation between nursing students' skills and knowledge about intramuscular injection at P<0.0001. It can be concluded that nursing students from first year at Faculty of Nursing at Benha University have adequate knowledge, and skills of intramuscular injection. So, it was recommended that prime importance for nursing educators pays further attention to nursing students' training about intramuscular injection.