The aim of this study was to investigate the utilization of self-care brochure for relieving mother's minor discomforts during pregnancy. Methods: An interventional quasiexperimental research design was carried out at Antenatal Clinic of Mansoura University Hospital-Mansoura City on 90 primigravida women at ≤34 gestational weeks, who were selected by simple random sampling technique. They were free from any medical and obstetric problems, can read and write, and reported one or more of the associated pregnancy minor discomforts. They were divided into either control or intervention group 45 per each group. The intervention group: had received a self-care brochure beside the routine antenatal care. While the control group had received the routine antenatal care only. Mother's attitude regarding self-care was assessed utilizing Likert scale. Results: Providing the pregnant mothers with a self-care brochure was associated with relieving most of the self-reported pregnancy discomforts among the study group compared to those of the control group as reported by women 3 weeks post intervention. Conclusion: the intervention group had agreed that the self-care guide is easy to be used and the majority of them reported that they will use it in the future pregnancy.