Infection is one of the leading causes of morbidity and mortality in liver transplant recipients. Nurses play a key role in infection prevention so that improvement of the practices of the nurses is an important aspect of infection control thus decreases morbidity and mortality. Aim of the study:evaluate the effect of the educational strategies on improving nurses' performance in caring patients undergoing liver transplantation. Method:A quasi experimental was used. It was conducted in surgical word (transplant unit) at Gastro-Enterology Center at Mansoura university hospital.Subjects: All available nurses (30), who provide direct care for liver transplant recipients. Tool: two tools were used 1- Pre-post designed questionnaire sheet, 2- Observation checklists sheet.Results:the result of this study showed significant progress in nurses' knowledge and practices in post/test; the mean scores of nurse's knowledge before implementation of the strategy was 16.36 and after implementation the strategies this mean improved to 21.16.and the mean scores of nurse's practice before implementation the strategies were 82.80and after implementation the strategies this mean improved to147.68.Conclusion: that, by the implementation of the program there was remarkable improvement of nurses' knowledge and practices; it was clear in post-test results.